THERE IS VIRTUALLY NO EFFECTIVE WAY TO DELIVER AND RETAIN POTENT BIOLOGICS AT IMPLANTATION SITES
Devices do not retain therapeutic proteins at implant sites
Systemic delivery of regenerative therapeutic proteins is not sufficiently targeted to be effective
Devices are ill-suited to deliver biologics and biologics are ill-suited for targeted delivery. Our work bridges this divide. With our platform we can turn virtually any implant into a biologic delivery device – effectively a “biodevice”.
Bone Morphogenetic Protein 2 (BMP2) is a very potent protein that induces bone formation wherever it is placed. Despite the excellent spinal fusion rates promoted by this powerful molecule, adverse safety outcomes associated with BMP2 have limited its use.
We developed a proprietary variant called AMP2 (targetable BMP2) that binds devices extremely tightly. It allows for precise bone regeneration, greater efficacy, safety, and ease of use.